Isothermal microcalorimetry providess an extremely sensitive measurement of the metabolic activity of the cells in real-time. The readout can be used for understanding and quantifying the impact of new anti-cancer treatments. 2D cell cultures, 3D cell cultures and tissue biopsies can be used for the evaluation from screening to clinical development.
Drug testing in physiologically relevant environments
Microcalorimetry can offer better prediction power than typical endpoint assays, by allowing you to run samples of any morphology in real-time.
Whether you’re using cell lines, primary cells, or a biopsy, the calScreener™ can give you new insights into cancer metabolism by measuring the smallest alteration in metabolic processes closer than any other assays. This can be crucial for drug discovery and development, as you can achieve accurate in-vivo prediction early in the process, reducing the risk and costs associated with unsuitable drug candidates making it too far down the pipeline.
Rapid microcalorimetric drug response assessment can refine a general treatment concept when it is applied in cases in which tumors do not respond to conventional chemo-radiation treatment. For solid tumors, which do not respond to classical treatment, and especially for rare tumors without an established protocol rapid microcalorimetric drug response testing presents an elegant novel approach to test alternative therapeutic approaches.
Monitor the total metabolic activity
Only technique that directly measures the metabolic state of cells, eliminating the need for proxies and dyes. With the calScreener™ you can
measure on all types of cells and conditions, allowing you to see how treatment, different media, and experimental environments affect the total metabolic response of your system.
Data courtesy of Dr. Stephanie J. Gros, Uneversity Children’’s Hospital, Basel
Measure the metabolic activity of cancer cells
As illustrated in this graph and analysis of NB cells, the maximum metabolic rate and total energy are proportional to the cell number.
Measure treatment effectiveness
The calScreener™ is a label-free and non-destructive assay, giving you the opportunity to perform post-experimental analysis on your samples, in the instrument itself or in any other type of analysis such as microscopy.
The caScreener’s unlimited runtime can be extremely useful for recovery experiments, as you can measure treatment effectiveness directly on the same samples, by changing the medium and re-inserting them in the calScreener™ to confirm survival of cancer cells.
The calScreener™ has been especially effective in investigating antibody treatments for cancer therapy. Our technology, thanks to its increased sensitivity, can complement the traditional antibody screening approach of using molecular markers.